Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1
نویسندگان
چکیده
Hepatitis C virus (HCV) infection remains a major health problem worldwide. HCV entry into host cells and membrane fusion are achieved by two envelope glycoproteins, E1 and E2. We report here the 3.5-Å resolution crystal structure of the N-terminal domain of the HCV E1 ectodomain, which reveals a complex network of covalently linked intertwined homodimers that do not harbour the expected truncated class II fusion protein fold.
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عنوان ژورنال:
دوره 5 شماره
صفحات -
تاریخ انتشار 2014